abm hsa mir mirna Entrez Gene

Entrez Gene Summary for MIR425 Gene

MicroRNAs (miRNAs) are fast (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting every the soundness and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated major transcripts (pri-miRNAs) which may be each protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to offer an roughly 70-nt stem-loop precursor miRNA (pre-miRNA), which is extra cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) merchandise. The mature miRNA is built-in proper right into a RNA-induced silencing sophisticated (RISC), which acknowledges objective mRNAs via imperfect base pairing with the miRNA and largely ends in translational inhibition or destabilization of the objective mRNA. The RefSeq represents the anticipated microRNA stem-loop.

Abstract

Necessary progress has been made inside the remaining decade in our understanding of the pathogenetic mechanisms of colorectal most cancers (CRC). Most cancers stem cells (CSC) have gained loads consideration and are literally believed to play an important place inside the pathogenesis of various cancers, along with CRC. Inside the current analysis, we validated gene expression of four genes related to CSC, L1TD1, SLITRK6, ST6GALNAC1 and TCEA3, acknowledged in a earlier bioinformatics analysis.

The expression of chosen genes and microRNAs (miRNAs) was evaluated using quantitative PCR. Differential expression of all investigated genes and four of six prioritized miRNAs (hsa-miR-199a-3p, hsa-miR-335-5p, hsa-miR-425-5p, hsa-miR-1225-3p, hsa-miR-1233-3p and hsa-miR-1303) was current in in any case one group of CRC cancerogenesis. L1TD1, SLITRK6, miR-1233-3p and miR-1225-3p have been correlated to the extent of malignancy.

A detrimental correlation between miR-199a-3p and its predicted objective SLITRK6 was seen, displaying potential for added experimental validation in CRC. Our outcomes current extra proof that CSC-related genes and their regulatory miRNAs are involved in CRC enchancment and improvement and counsel that some them, considerably miR-199a-3p and its SLITRK6 objective gene, are promising for added validation in CRC.

hsa-miR-1181 miRNA Antagomir
MNH01061	ABM	2 x 5.0 nmol	EUR 394.8

hsa-miR-1182 miRNA Antagomir
MNH01062	ABM	2 x 5.0 nmol	EUR 394.8

hsa-miR-1183 miRNA Antagomir
MNH01063	ABM	2 x 5.0 nmol	EUR 394.8

hsa-miR-1184 miRNA Antagomir
MNH01064	ABM	2 x 5.0 nmol	EUR 394.8

hsa-miR-1185 miRNA Antagomir
MNH01065	ABM	2 x 5.0 nmol	EUR 394.8

hsa-miR-1193 miRNA Antagomir
MNH01069	ABM	2 x 5.0 nmol	EUR 394.8

hsa-miR-1197 miRNA Antagomir
MNH01070	ABM	2 x 5.0 nmol	EUR 394.8

hsa-miR-1200 miRNA Antagomir
MNH01073	ABM	2 x 5.0 nmol	EUR 394.8

hsa-miR-1201 miRNA Antagomir
MNH01074	ABM	2 x 5.0 nmol	EUR 394.8

hsa-miR-1202 miRNA Antagomir
MNH01075	ABM	2 x 5.0 nmol	EUR 394.8

hsa-miR-1203 miRNA Antagomir
MNH01076	ABM	2 x 5.0 nmol	EUR 394.8

hsa-miR-1204 miRNA Antagomir
MNH01077	ABM	2 x 5.0 nmol	EUR 394.8

hsa-miR-1205 miRNA Antagomir
MNH01078	ABM	2 x 5.0 nmol	EUR 394.8

hsa-miR-1206 miRNA Antagomir
MNH01079	ABM	2 x 5.0 nmol	EUR 394.8

hsa-miR-1208 miRNA Antagomir
MNH01082	ABM	2 x 5.0 nmol	EUR 394.8

hsa-miR-1226 miRNA Antagomir
MNH01090	ABM	2 x 5.0 nmol	EUR 394.8

hsa-miR-1227 miRNA Antagomir
MNH01093	ABM	2 x 5.0 nmol	EUR 394.8

hsa-miR-1228 miRNA Antagomir
MNH01096	ABM	2 x 5.0 nmol	EUR 394.8

hsa-miR-1229 miRNA Antagomir
MNH01099	ABM	2 x 5.0 nmol	EUR 394.8

hsa-miR-1231 miRNA Antagomir
MNH01102	ABM	2 x 5.0 nmol	EUR 394.8

hsa-miR-1233 miRNA Antagomir
MNH01103	ABM	2 x 5.0 nmol	EUR 394.8

hsa-miR-1234 miRNA Antagomir
MNH01106	ABM	2 x 5.0 nmol	EUR 394.8

hsa-miR-1236 miRNA Antagomir
MNH01108	ABM	2 x 5.0 nmol	EUR 394.8

hsa-miR-1237 miRNA Antagomir
MNH01111	ABM	2 x 5.0 nmol	EUR 394.8

hsa-miR-1238 miRNA Antagomir
MNH01114	ABM	2 x 5.0 nmol	EUR 394.8

hsa-miR-1243 miRNA Antagomir
MNH01118	ABM	2 x 5.0 nmol	EUR 394.8

hsa-miR-1244 miRNA Antagomir
MNH01120	ABM	2 x 5.0 nmol	EUR 394.8

hsa-miR-1245 miRNA Antagomir
MNH01121	ABM	2 x 5.0 nmol	EUR 394.8

hsa-miR-1246 miRNA Antagomir
MNH01126	ABM	2 x 5.0 nmol	EUR 394.8

hsa-miR-1247 miRNA Antagomir
MNH01127	ABM	2 x 5.0 nmol	EUR 394.8

hsa-miR-1248 miRNA Antagomir
MNH01130	ABM	2 x 5.0 nmol	EUR 394.8

hsa-miR-1249 miRNA Antagomir
MNH01131	ABM	2 x 5.0 nmol	EUR 394.8

hsa-miR-1250 miRNA Antagomir
MNH01134	ABM	2 x 5.0 nmol	EUR 394.8

hsa-miR-1251 miRNA Antagomir
MNH01137	ABM	2 x 5.0 nmol	EUR 394.8

Entrez Gene Summary for MIR425 Gene

Abstract

hsa-miR-1181 miRNA Antagomir

hsa-miR-1182 miRNA Antagomir

hsa-miR-1183 miRNA Antagomir

hsa-miR-1184 miRNA Antagomir

hsa-miR-1185 miRNA Antagomir

hsa-miR-1193 miRNA Antagomir

hsa-miR-1197 miRNA Antagomir

hsa-miR-1200 miRNA Antagomir

hsa-miR-1201 miRNA Antagomir

hsa-miR-1202 miRNA Antagomir

hsa-miR-1203 miRNA Antagomir

hsa-miR-1204 miRNA Antagomir

hsa-miR-1205 miRNA Antagomir

hsa-miR-1206 miRNA Antagomir

hsa-miR-1208 miRNA Antagomir

hsa-miR-1226 miRNA Antagomir

hsa-miR-1227 miRNA Antagomir

hsa-miR-1228 miRNA Antagomir

hsa-miR-1229 miRNA Antagomir

hsa-miR-1231 miRNA Antagomir

hsa-miR-1233 miRNA Antagomir

hsa-miR-1234 miRNA Antagomir

hsa-miR-1236 miRNA Antagomir

hsa-miR-1237 miRNA Antagomir

hsa-miR-1238 miRNA Antagomir

hsa-miR-1243 miRNA Antagomir

hsa-miR-1244 miRNA Antagomir

hsa-miR-1245 miRNA Antagomir

hsa-miR-1246 miRNA Antagomir

hsa-miR-1247 miRNA Antagomir

hsa-miR-1248 miRNA Antagomir

hsa-miR-1249 miRNA Antagomir

hsa-miR-1250 miRNA Antagomir

hsa-miR-1251 miRNA Antagomir

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